Metabolism of vitamin D3-3H in vitamin D-resistant rickets and familial hypophosphatemia.

نویسندگان

  • L V Avioli
  • T F Williams
  • J Lund
  • H F DeLuca
چکیده

The fate of an intravenous dose of tritiated vitamin D(3) was studied in seven normal subjects, four children with vitamin D-resistant rickets, and four adults with a familial history of vitamin D-resistant rickets and persistent hypophosphatemia. An abnormal metabolism of vitamin D in vitamin D-resistant rickets was defined and characterized by a decrease in the plasma fractional turnover rate, a marked increase in plasma water-soluble metabolites, and a relative decrease in the conversion of vitamin D to a polar, biologically active metabolite. Alterations in vitamin D metabolism in the adults with persistent hypophosphatemia were similar but less severe than those of affected children with vitamin D-resistant rickets. It is tentatively concluded that the abnormalities in vitamin D metabolism documented in patients with vitamin D-resistant rickets and familial hypophosphatemia may account for the observed osseous and biochemical changes.

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عنوان ژورنال:
  • The Journal of clinical investigation

دوره 46 12  شماره 

صفحات  -

تاریخ انتشار 1967